Health Report Area 3a

Nomenclature B6.129P2-Apoetm1UncJ/Arc
Product code APOE
JAX stock number 002052
Strain Description Mutant inbred
Coat Colour Black (a/a)
MHC Haplotype H2Kb
Complement Factor C5 normal
  • Mice homozygous for the Apoetm1Unc  mutation show a marked increase in total plasma cholesterol levels that are unaffected by age or sex.
  • Fatty streaks in the proximal aorta are found at 3 months of age. The lesions increase with age and progress to lesions with less lipid but more elongated cells, typical of a more advanced stage of pre-atherosclerotic lesion.
  • Moderately increased triglyceride levels have been reported in mice with this mutation on a mixed C57BL/6 x 129 genetic background.
  • Aged apoE-deficient mice (>17 months) have been shown to develop xanthomatous lesions in the brain consisting mostly of crystalline cholesterol clefts, lipid globules, and foam cells. Smaller xanthomas were seen in the choroid plexus and ventral fornix.
  • Recent studies indicate that apoE-deficient mice have altered responses to stress, impaired spatial learning and memory, altered long term potentiation, and synaptic damage.
  • See www.jax.org for more strain information.
  • These mice are sold subject to The Jackson Laboratory’s Conditions of Use and also the Australian Patent Number (2004268530). Information regarding conditions of use is available at: Jax General Terms and Conditions.