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LPK

Health Report

 

Nomenclature: LEW-Nek8lpk/SsNArc

Product code: LPK

Strain Description: Mutant Inbred

Coat Colour: Albino (a, B, c, h)

MHC Haplotype: RT1l

  • Docile.
  • Lewis (LEW/SsNArc) rat is the background strain.
  • Lewis polycystic kidney (LPK) model of autosomal-recessive polycystic kidney disease (ARPKD).
  • Lewis rats (LEW/SsNArc) with PKD arose as a spontaneous mutation of Nek8 (McCooke, et al., A novel mutation causing Nephronophthisis in the Lewis Polycystic Kidney rat localises to a conserved RCC1 domain in Nek8. BMC Genomics, 2012, 13: 393).
  • Bilateral PKD starts as early as 3 weeks and progresses with age in homozygous animals (Kidney Blood Pressure Research 2007; 30: 129-144).
  • Develop hypertension in homozygous animals and susceptible to induction of experimental allergic encephalomyelitis.