| Nomenclature |
C.B-17/IcrHanHsd-Prkdcscid/ARC |
| Product code |
SCID |
| Strain Description |
Mutant inbred |
| Coat Colour |
Albino (A/A Tyrp1b/Tyrp1b Tyrc/Tyrc) |
| MHC Haplotype |
H2Kd |
| Complement Factor |
C5 normal |
- Arose as a spontaneous autosomal recessive mutation in C.B-Igh-1b (CB-17) congenic strain. Prkdcscid (autosomal recessive, protein kinase, DNA activated, catalytic polypeptide).
- Homozygotes have little or no immunoglobulin in serum. Lymphoid organs consist of vascular connective tissue and macrophages and are devoid of lymphocytes.
- Bone marrow lacks plasma cells and lymphocytes and skin lacks dendritic Thy-1+ epidermal cells. Although B and T-cells and pre-B and pre-T cells are absent early B and T-cells are present.
- A variable percentage (2-20%) of young adults develops low numbers of functional B and T-cells. This is not genetically determined.
- Macrophage activation and antigen presentation, NK cell activity and myeloid cell differentiation is normal.
- Useful model for studying the relationship between immunity and disease, studies on engraftment of xenogenic cells and tissues and studying human severe combined immunodeficiency.
- Also a useful model for understanding the basis of increased lymphoid malignancies in immunodeficiencies as thymic lymphomas occurs in about 15% of mice.
- Cystitis in female stock.
- Housed in an isolator.
|
|
|
