Ptprca[a]J

Health Report Area 3a

Nomenclature B6.SJL-Ptprc^aPepc^b/BoyJArc
Product code	PTP
Strain Description	Congenic Created by transferring through backcrossing the Ptprc^a and Pepc^b genes of the inbred strain SJL/J onto the C57BL/6 background.
Coat Colour	Black (a/a)
MHC Haplotype	H2K^b
Complement Factor	C5 normal
Confusion has occurred over the years due to changes in nomenclature of the T-Lymphocyte cell surface antigen CD45. Ptprc^a (protein-tyrosine phosphatase, receptor type c) was the gene symbol designated to the CD45 antigen because of its homology with human placental protein-tyrosine phosphatase 1B. Ptprc^a is one of a family of protein-tyrosine phosphatase genes involved with the regulation of cell growth. Congenital abnormalities include microphthalmia, corneal opacities, anophthalmia, hydrocephalus and portosystemic shunts. See www.jax.org for more strain information. These mice are sold subject to The Jackson Laboratory’s Conditions of Use and also the Australian Patent Number (2004268530). Information regarding conditions of use is available at: Jax General Terms and Conditions.