| Nomenclature |
|JAX stock number||007799|
|Strain Description||Targeted (Null/Knockout)|
|Coat Colour||Albino (A/A Tyrc/Tyrc)|
- These NRG mice are NOD-congenic mice harboring the Rag1null mutation (Rag1KO or Rag1tm1Mom) on chromosome 2 and the IL2rγnull mutation (IL2RγcKO or Il2rgtm1Wjl) on the X chromosome.
- These NRG mutant mice are also called NOD-Rag1null IL2rγnull double mutant mice or NOD.Rag1KO.IL2RγcKO mice. Females homozygous for both mutations (and males homozygous for Rag1null; hemizygous for the X-linked IL2rγnull mutation) are viable and fertile.
- When compared to NOD-scid IL2rgnull mice (NSG) these NRG mice tolerate much higher levels of irradiation conditioning. Additionally, NRG mice support higher levels of both human cord blood stem cell engraftment following irradiation-conditioning (leading to multi-lineage hematopoietic cell populations and a complete repertoire of human immune cells, including human T cells) and human peripheral blood mononuclear cells engraftment in unconditioned adult mice with respect to NOD-Rag1null (Jax No. 003729) or NOD-scid (Jax No.001303) mice.
- These NRG mice may be useful for cell or tissue transplantation studies, particularly as a model for human lymphohematopoietic cell engraftment studies that require a radioresistant host.
- Due to their level of immunodeficiency NRG mice need to be maintained in a ‘maximum barrier’. A description of maximum barrier conditions and practices is available on the Jax website. Housed in isolators at the ARC.
- Further detailed information is also available at: http://jaxmice.jax.org/strain/007799.html
These mice are sold subject to The Jackson Laboratory’s Conditions of Use and also the Australian Patent Number (2004268530). Information regarding conditions of use is available at: http://jaxmice.jax.org/cou/index.html