Area 4b Health Report

Nomenclature WKY/NCrlArc (Wistar Kyoto)
Product code WKY
Strain Description Inbred
Coat Colour Albino (aBch)
MHC Haplotype RT1l
  • Adult WKY have an inability to excrete acid appropriately after acute or chronic acid loading compared to Sprague Dawley rats.
  • A subset of WKY originating at NIH demonstrates an inheritable transmission of biventricular cardiac hypertrophy (BVH).
  • WKY with BVH provide a natural model of volume load hypertrophy.
  • Recognised normotensive control to use in parallel with studies involving the hypertensive SHR rat.