Health Report

Nomenclature NOD.CB17-Prkdcscid/Arc
Product code NODSCID
Strain Description Mutant inbred
Coat Colour Albino (A/A Tyrc/Tyrc)
MHC Haplotype H2Kg7
Complement Factor C5 deficient
  • The Animal Resources Centre received breeding pairs from colonies held at the Walter and Eliza Hall Institute in December 1998.
  • Average breeding performance (high mortality in breeders; aggressive).
  • Refer to NOD/ShiLtJArc.
  • Prkdcscid – autosomal recessive, protein kinase, DNA activated, catalytic polypeptide.
  • No endogenous T- or B- lymphocyte function.
  • Develops high incidence of thymoma with age and old mice can develop inclusion body nephropathy.
  • Used for the delineation of the role of T cell subsets and auto-antibodies in diabetes.
  • Housed in an isolator.
  • Often used as the ‘control’ for NOD/ShiLtJArc.