Health Report

Nomenclature C.B-17/IcrHanHsd-Prkdcscid/ARC
Product code SCID
Strain Description Mutant inbred
Coat Colour Albino (A/A Tyrp1b/Tyrp1b Tyrc/Tyrc)
MHC Haplotype H2Kd
Complement Factor C5 normal
  • Arose as a spontaneous autosomal recessive mutation in C.B-Igh-1b (CB-17) congenic strain. Prkdcscid (autosomal recessive, protein kinase, DNA activated, catalytic polypeptide).
  • Homozygotes have little or no immunoglobulin in serum. Lymphoid organs consist of vascular connective tissue and macrophages and are devoid of lymphocytes.
  • Bone marrow lacks plasma cells and lymphocytes and skin lacks dendritic Thy-1+ epidermal cells. Although B and T-cells and pre-B and pre-T cells are absent early B and T-cells are present.
  • A variable percentage (2-20%) of young adults develops low numbers of functional B and T-cells. This is not genetically determined.
  • Macrophage activation and antigen presentation, NK cell activity and myeloid cell differentiation is normal.
  • Useful model for studying the relationship between immunity and disease, studies on engraftment of xenogenic cells and tissues and studying human severe combined immunodeficiency.
  • Also a useful model for understanding the basis of increased lymphoid malignancies in immunodeficiencies as thymic lymphomas occurs in about 15% of mice.
  • Cystitis in female stock.
  • Housed in an isolator.