Ptprca[a]J

Nomenclature B6.SJL-Ptprc a Pepc b /BoyJArc
Product code PTP
Strain Description Congenic Created by transferring through backcrossing the Ptprca and Pepcb/BoyJ genes of the inbred strain SJL/J onto the C57BL/6 background.
Coat Colour Black (a/a)
MHC Haplotype H2Kb
Complement Factor C5 normal
  • Poor breeding performance (refer to C57Bl/6J).
  • Confusion has occurred over the years due to changes in nomenclature of the T-Lymphocyte cell surface antigen CD45.
  • Ptprca (protein-tyrosine phosphatase, receptor type c) was the gene symbol designated to the CD45 antigen because of its homology with human placental protein-tyrosine phosphatase 1B. Ptprca is one of a family of protein-tyrosine   phosphatase genes involved with the regulation of cell growth.
  • Congenital abnormalities include microphthalmia, corneal opacities, anophthalmia and hydrocephalus.
  • Susceptible to imperforate vaginas, divided septums and mucometra.
Ptprca   Health Report