Ptprca[a]J

Aea 1 – Health Report

Area 3 – Health Report

 
Nomenclature                                                 B6.SJL-PtprcaPepcb/BoyJArc
Product code PTP
Strain Description Congenic Created by transferring through backcrossing the Ptprca and Pepcb genes of the inbred strain SJL/J onto the C57BL/6 background.
Coat Colour Black (a/a)
MHC Haplotype H2Kb
Complement Factor C5 normal
  •   Confusion has occurred over the years due to changes in nomenclature of the T-Lymphocyte cell surface antigen CD45.
  • Ptprca (protein-tyrosine phosphatase, receptor type c) was the gene symbol designated to the CD45 antigen because of its homology with human placental protein-tyrosine phosphatase 1B. Ptprca is one of a family of protein-tyrosine phosphatase genes involved with the regulation of cell growth.
  • Congenital abnormalities include microphthalmia, corneal opacities, anophthalmia, hydrocephalus and portosystemic shunts.
  • See www.jax.org  for more strain information.
  • These mice are sold subject to The Jackson Laboratory’s Conditions of Use and also the Australian Patent Number (2004268530). Information regarding conditions of use is available at: http://jaxmice.jax.org/cou/index.html.