| Nomenclature |
NOD/ShiLtJArc |
| Product code |
NOD |
| JAX stock number |
001976 |
| Strain Description |
Inbred |
| Coat Colour |
Albino (A/A Tyrc/Tyrc) |
| MHC Haplotype |
H2Kg7 |
| Complement Factor |
C5 deficient |
- Strain was formerly called NOD/LtJ until 2007 when it was changed to NOD/ShiLtJ.
- This strain is used in immunology and inflammation research and is a polygenic model for type 1 diabetes.
- The Jackson Laboratory reports that diabetes occurs in 90-100% of females by 30 weeks of age and 40-60% of males by 30-40 weeks of age.
- Susceptibility to diabetes is polygenic and environment factors such as housing conditions, health status and diet exert a strong effect on penetrance.
- Females produce 4 to 5 litters before becoming diabetic.
- Female breeders are aggressive.
- The incidence of diabetes in males is influenced by environmental factors including pathogens in an inverse relationship i.e. higher incidence of diabetes in germfree animals than conventional animals.
- Mice free from diabetes by 1 year are prone to develop follicle centre cell lymphomas.
- See www.jax.org for more strain information.
- These mice are sold subject to The Jackson Laboratory’s Conditions of Use and also the Australian Patent Number (2004268530). Information regarding conditions of use is available at: Jax General Terms and Conditions.
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