NOD/LtJ

Health Report

Nomenclature NOD/ShiLtJArc
Product code NOD
JAX stock number 001976
Strain Description Inbred
Coat Colour Albino (A/A Tyrc/Tyrc)
MHC Haplotype H2Kg7
Complement Factor C5 deficient
  • Strain was formerly called NOD/LtJ until 2007 when it was changed to NOD/ShiLtJ.
  • This strain is used in immunology and inflammation research and is a polygenic model for type 1 diabetes.
  • The Jackson Laboratory reports that diabetes occurs in 90-100% of females by 30 weeks of age and 40-60% of males by 30-40 weeks of age.
  • Susceptibility to diabetes is polygenic and environment factors such as housing conditions, health status and diet exert a strong effect on penetrance.
  • Females produce 4 to 5 litters before becoming diabetic.
  • Female breeders are aggressive.
  • The incidence of diabetes in males is influenced by environmental factors including pathogens in an inverse relationship i.e. higher incidence of diabetes in germfree animals than conventional animals.
  • Mice free from diabetes by 1 year are prone to develop follicle centre cell lymphomas.
  • See www.jax.org for more strain information.
  • These mice are sold subject to The Jackson Laboratory’s Conditions of Use and also the Australian Patent Number (2004268530). Information regarding conditions of use is available at: http://jaxmice.jax.org/cou/index.html.
  NOD Lt