| Nomenclature |
C57BL/6JArc |
| Product code |
B6 |
| JAX stock number |
000664 |
| Strain Description |
Inbred |
| Coat Colour |
Black (a/a) |
| MHC Haplotype |
H2Kb |
| Complement Factor |
C5 normal |
- Susceptible to the development of atheromatous lesions after 20 weeks on high fat diets.
- Develops non-insulin dependent diabetes mellitus and hypertension when fed a high/fat, high simple-carbohydrate diet.
- Glucose intolerance is due to spontaneous mutation in Nicotinamide Nucleotide Transhydrogenase (Nnt).
- Generally refractory to many tumours and to many infectious agents.
- Congenital abnormalities include microphthalmia, corneal opacities, anophthalmia and hydrocephalus (Smith, R.S., Roderick, T.H. and Sundberg, J.P., 1994).
- Susceptible to imperforate vaginas and mucometra.
- White spotting commonly observed in pigmentation.
- Aggressiveness observed in male stock from 6 weeks of age and female breeders.
- Fighting amongst males increases when cohorts are divided into smaller groups.
- Barbering and ulcerative dermatitis observed.
- See www.jax.org for more strain information.
- These mice are sold subject to The Jackson Laboratory’s Conditions of Use and also the Australian Patent Number (2004268530). Information regarding conditions of use is available at: Jax General Terms and Conditions.
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